The evolution of callus formation after stimulation with bone graft and bone marrow aspirate from iliac crest

Background. The experimental research studies the behaviour of open fracture site after stimulation with cortical-cancelleous graft and medular aspirate from iliac crest. Methods. The animal used was home rabbit, because he has an anatomy which permit the bone study. The animals were divided in 4 study groups due to the callus stimulation method and the aspect of fracture site (simple, comminuted). For each group of study, the evaluation was made separately, due to the osteosynthesis type, resulting subgroups of reasearch. Results. The evaluation of the results was made by clinical, histological and radiological study comparing the research groups, at established periods of time. The final evaluation was made at 6 weeks, by calculating clinical, radiological and histological scores with high specificity, which permited a correct interpretation of the obtained results. Conclusions. The study confirms the role of the bone marrow and of the cortico-cancellous bone graft in ostheogenesis, in which the osteoprogenitors cells survive permamently and have an important role to stimulate and to accelerate consolidation.