Spondyloarthritis is a disease that creates a serious burden to the medical sector. This condition is defined by inflammatory spinal stiffness that affects the cartilaginous spinal joints and the sacroiliac joints. An 18 years old male patient was hospitalized because of spondyloarthritis, though no known family history of spondyloarthritis and uveitis were manifested. Diagnoses of HLA-B27-positive spondyloarthritis with mostly peripheral involvement were proposed in laboratory testing. X-ray report of pelvis and both S.I. joint were normal, so it confirmed this patient is affected by non-radiographic spondyloarthritis. Anti-inflammatory medications and steroids had little impact on the complaints, which were quite severe. Non-steroidal anti-inflammatory drugs, corticosteroids, and DMARDs are the medicines of preference but cannot give a comprehensive treatment in traditional approaches.