American football is a sports discipline involving a high-risk of injuries. The aim of the study is a quantitative analysis of injuries reported by the players. The following aspects have also been assessed: the behavior of the players after suffering from an injury, and the situations most often involving injuries. The research has been conducted on 218 players from teams included in the American Football Association in Poland (PZFA). The findings of the research have confirmed the thesis that American football is a high-risk sports discipline. The most often injured regions of the body have been ankle joint and foot.