The aim of this preliminary report is to present own experience in the OBI TrueFit graft application in case of osteochondral defect of the knee. The TruFit graft was applied in 6 cases (5 male and 1 female). The age of patients range from 19 to 48 years. The procedure was done arthroscopicly in 4 cases and via mini arthrotomy in 2 ones. The medial femoral condyle was involved in 5 cases and lateral condyle in one. The follow-up time range from 4 to 23 weeks. Rehabilitation permitted immediate full range of motion, non-weight bearing during 6 weeks with partial loding in the 6th postoperative week. There were not any intra operative and postoperative complication. The early MRI evaluation performed 12 weeks from surgery in one case provided a very promising data which supported TrueFit graft application in case of osteochondral defects of the knee.