Journal of Orthopaedics Trauma Surgery and Related Research

Journal of Orthopaedics Trauma Surgery and Related Research

An Official Journal of Polish Society of Orthopaedics and Traumatology

ISSN:1897-2276
e-ISSN: 2449-9145

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Application of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in clinical practice according to a gastroenterologist

Author(s): Maciej Kierzkiewicz

NSAIDs are the basic and most commonly used drugs with documented efficacy in the treatment of inflammatory and pain. Effect of NSAIDs is associated with the inhibition of cyclooxygenases. The reason of most of the adverse effects of NSAIDs is inhibition of COX- 1 and therapeutic effect depends on the inhibition of COX-2. Side effects of NSAIDs may occur more than half of patients and is particularly relevant in the gastrointestinal tract, followed by cardiovascular system or other organs. The most common symptoms are dyspeptic, but it can also lead to gastrointestinal bleeding or perforation, and it can even cause death of the patient. It has been shown that the lowest risk of bleeding from the upper gastrointestinal tract are present in the application of ibuprofen, nimesulide, diclofenac and dexketoprofen. Very important is individual to the patient’s choice correct form and method of administration of drug.


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Annals of Medical and Health Sciences Research Journal of Orthopaedics Trauma Surgery and Related Research a publication of Polish Society, is a peer-reviewed online journal with quaterly print on demand compilation of issues published.
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