Journal of Orthopaedics Trauma Surgery and Related Research

Journal of Orthopaedics Trauma Surgery and Related Research

An Official Journal of Polish Society of Orthopaedics and Traumatology

ISSN:1897-2276
e-ISSN: 2449-9145

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Current opinions on methyloprednisolone therapy in acute spinal cord injury and alternative pharmacological treatment

Author(s): TOMASZ POTACZEK, KATARZYNA KĄCKA

Introduction: Acute spinal cord injuries (ASCI) and their consequences still are a challenge for doctors of various specialities. Current concepts of ASCI pathophysiology underline the role of secondary damage therein membrane lipid peroxydation and nerve cells apoptosis. Hopes for effective decrease of these phenomenons were bound with methyloprednisolone therapy after encouraging results of American NASCIS I, II and III trials. Presently methyloprednisolone treatment is widely discussed and the efficacy is uncertain. Aim of paper: Authors basing on current literature present concepts of posttraumatic changes in spinal cord after ASCI, mechanisms of methyloprednisolone action, advantages and disadvantages of this therapy. Based on long term observations methyloprednisolone treatment does not fulfil expectations, furthermore NASCIS trials lack accurate evaluation and adverse reactions like gastro-intestinal bleeding, infections and prolonged hospitalisation outweigh benefits. Future directions of pharmacological treatment are presented. Conclusion: All gathered data suggest that methyloprednisolone therapy in ASCI is not efficient and can not be treated as therapeutical standard. Initial results of methyloprednisolone therapy were not confirmed in following studies. Current pharmacological research is focused on neuroprotective and antioxidant treatment e.g. erythropoetin, estrogen or activated autologic macrophages.


+44 7480724769
Indexed in

Scopus Embase/EXPERTA MEDICA Road Directory of Open Access
Scholarly Resources
Publons MIAR GBL Ministry of Science and Higher
Education
Index Copernicus
SCImago Journal & Country Rank
Annals of Medical and Health Sciences Research Journal of Orthopaedics Trauma Surgery and Related Research a publication of Polish Society, is a peer-reviewed online journal with quaterly print on demand compilation of issues published.
Submit your Manuscript

Recommended Conferences