The work carried out to analyze the reaction centers of the brain in the treatment of patients with humeral fracture. Systolic linear blood flow velocity in the brachial and middle cerebral artery was measured in 18 patients with humeral fracture treated with the Ilizarov external fixation using Doppler ultrasound to assess hypothesis of changes in the functional condition of cerebral centres. The age of patients from 22 to 86 years. In patients during treatment and after it conducted psychophysiological testing (test SF-36). Blood flow was shown to accelerate in both the brachial artery (123%) and the middle cerebral artery from the opposite side (137%) within 2 to 4 weeks of the bone fixation. The increase was dependent on intensity of the pain and was shown to be less in middle adulthood and elderly patients. Blood flow velocity was shown to increase in the arteries of injured segment and the middle cerebral artery of the contralateral side during humerus fracture repair. Amount of accelerated blood velocity caused by limb injury in the middle cerebral artery of the contralateral side was shown to decrease with increased patients’ age due to low reactivity of the brain arteries.