Journal of Orthopaedics Trauma Surgery and Related Research

Journal of Orthopaedics Trauma Surgery and Related Research

An Official Journal of Polish Society of Orthopaedics and Traumatology

e-ISSN: 2449-9145

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Efficacy of single dose versus multiple dose injectable antibiotics in hip joint surgery

Author(s): Nishit Bhatnagar*, Sumit Sural, Sumit Arora, Purushotham Lingaiah and Anil Dhal

Objective: To compare the efficacy of two prophylactic antibiotic regimens in preventing surgical site infection. Setting: Tertiary level hospital in India.

Methods: We enrolled 104 consecutive patients undergoing elective implant surgery around the hip and randomized them into two groups. Group A (53) received a single dose of injectable cefazolin prior to skin incision, while group B (51) received additional 5 doses of injection cefazolin 12 hourly after the procedure. They were followed up for a minimum duration of 12 months and observed for the evidence of surgical site infection.

Results: None of the patients from group A had surgical site infection, while 3 patients of group B (5.8%) developed infection. However, difference in infection rate was not significant statistically (p=0.114). Staphylococcus was isolated from 2 of the 3 infected surgical sites and Klebsiella from the third.

Conclusion: Additional postoperative doses of cefazolin offer no advantage over its single pre-operative dose.

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Annals of Medical and Health Sciences Research Journal of Orthopaedics Trauma Surgery and Related Research a publication of Polish Society, is a peer-reviewed online journal with quaterly print on demand compilation of issues published.
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