Regenerative medicine is acknowledged as one of the world’s most rapidly evolving fields of study. Researchers in reconstructive surgery have recently proposed employing stem cells and biomaterials to repair bone injuries. From individual cells to entire tissues and organs, biomechanical environments are crucial. Additionally helpful in the process of bone restoration, these settings. At the location of injury, mechanical signals regulate biological activity. These signals control how various cells develop, differentiate, and proliferate. Additionally, they are in charge of the development of connective tissue and the stabilisation of broken bones. Cells receive mechanical signals via internal or external sources.
The effective and active forces that affect stem cell fate, such as shear stress, tension, elasticity, stiffness, etc., are first introduced and reviewed in this article. Next, we examine the data derived from experimental research and clinical observations about the impact of mechanobiology on stem cell differentiation or bone healing. Additionally, we have compiled the results of current investigations in a number of tables.