Fifty-one patients who had been admitted to Saint Paul Hospital and Hanoi Medical University Hospital for Anterior Cruciate Ligament (ACL) reconstruction were asked to complete a detailed questionnaire at preoperative and three-month postoperative time. The questionnaire designed to evaluate the improvement of Patient-reported Outcomes Measurement Information System (PROMIS) include Physical Function (PF), Pain Interference (PI), Depression (D) and Anxiety (A) scores before surgery with those taken 3 months after primary ACL reconstruction. The improvement score of PF domain increase to 10,17 ± 8,7; PI, D, A domain decrease to 9,63 ± 7,21; 10,02 ± 6,63 and 12,51 ± 7,58 respectively. At 3-month postoperative, all of the patients had better scores and had a statistically significant difference (p<0,05). All patients with ACL reconstruction had substantial improvement in pain reduction and regain physical function at 3-month after surgery.