Introduction. Toxic Epidermal Necrosis (TEN) also called Lyell’s syndrome is a rare dermatological condition that involves topical changes such as mucosal-dermal exfoliation as well as systemic changes. It occurs both in children and in adults, predominantly before 5 years of age and following 64th year of age, more frequently in women than in man. Material and methods. The material comprised 8 men with a diagnosed Lyell’s syndrome treated in the Centre for Burn Treatment in the period of 2006 – 2010, aged29 - 86 years, with the mean of 52 years, (6 women – with the mean age of 44 years and 2 men – mean age of 77 years). The patients hospitalized in CBT were treated in other hospitals in the period of 3-22 days prior to admission. In each case, admission to our hospital was preceded by dermatological consultation and Lyell’s syndrome diagnosis. Results. In a comparative analysis of microbiological tests conducted in the subjects examined in our study and the data available in literature, it was confirmed that during the first days the etiological factors responsible for colonization and topical infections were Gram-positive microbes, while at later stages bacterial flora converted into Gram-negative. Exclusively in one case the colonization of the wound as well as nose vestibule with fungi of the genus Candida glabrata was established (patient transferred on the 8th day from the neurological ward). Conclusions. The therapy of patients with Lyell’s syndrome is interdisciplinary, calling for a cooperation between specialists in different fields such as internal medicine, anesthesia, ophthalmology, otolaryngology, psychiatry, physiotherapy.