Muscle insufficiency forms major obstacle to independent ambulation in patients with myelomeningocele. In those patients who are able to ambulate, however, early degenerative changes may lead to loss of function. We present a myelomeningocele patient who sustained nontraumatic knee dislocation that made her wheelchair bound. Total knee arthroplasty with the use of rotating-hinge implant was performed. Patient returned to her previous manner of ambulation. To our knowledge this is the first report of rotating-hinge knee arthroplasty in patient with myelomeningocele.