In the study herein seven cases of thrombolytic treatment during cardiopulmonary resuscitation (CPR) have been presented. In the group of patient under analysis heart function was not restored by means of fibrinolytic drugs during CPR in 3 cases (42,85%), in two cases the therapy ended in the recovery of normal heart function but the patients died within several following hours (28,57%), in two cases a therapeutic success was observed - the patients were discharged from hospital without neurological ailments (28,57%). The percentage of cases in which the return of spontaneous circulation (ROSC) occurred in the group under examination was tantamount to 57,14%. According to the data presented, the effectiveness of thrombolysis during CPR proved superior in patients below 60 years of age and in patients without accompanying multiple lesions of vital body organs and systems. In the group of patients analyzed no hemorrhagic conditions were detected in association with simultaneous thrombolytic drugs administration and resuscitation protocols performance. According to the observations made by the authors of the study herein thrombolytic treatment during CPR may prove essential in resuscitation procedures but the authors think it indispensable to specify the requirements of the patients’ eligibility for this sort of treatment and the criteria of the administration of fibrinolytic drugs.