An Official Journal of Polish Society of Orthopaedics and Traumatology
ISSN:1897-2276
e-ISSN: 2449-9145
Qena University Hospital, Qena, Egypt
Research Article
Efficacy of topical and intravenous tranexamic acid
(txa) in reducing blood loss in primary total knee
arthroplasty, a prospective randomized trial
Author(s):
Ahmed Khalifa*, Mohammad A Mahran, Mohammad K Abdelnasser, Hatem M Bakr, Yaser E Khalifa, Ahmed M Abdelaal and Galal Zaki Said
Introduction: Total Knee Arthroplasty (TKA) is a major Orthopaedic operation that involves significant blood loss due to extensive soft tissue release and bone cuts. Fibrinolysis is considered the major cause of postoperative bleeding after TKA surgery, pharmacologic agents such as (Tranexamic Acid) TXA, a plasminogen-activator inhibitor, have been employed to reduce perioperative blood loss and prevent the need for post-operative transfusion. Patients and methods: A prospective randomized study involving 75 patients over a period of 6 month in our arthroplasty unit at a tertiary referral orthopedic hospital. The patients were divided into three groups, 25 patients in each one. GI received 2 gms of intravenous TXA before tourniquet inflation, GII received 3 gms TXA in 100 ml saline intraarticular (topical) after capsular closure, GIII was a control group. The primary outcome measure w.. Read More»
Select your language of interest to view the total content in your interested language