Dave Urmi M

Department of Anaesthesiology, PDU Medical College, Rajkot, India

Publications

• Original Article
  Clinical efficacy of topical nanoemulsion diclofenac gel versus combination of nanoemulsion diclofenac with methyl salicylate in osteoarthritis of knee
  Author(s): Dave Mittal B*, Dave Urmi M and Savajiyani Dixit N
  
  Objectives: Topical nanoemulsion diclofenac gels have been introduced on the premise that they act by penetration and accumulation in underlying structures. The other principle of action of topical preparations is “The gate theory of pain” or “Counter irritant principle”. Relative merit of these theories in clinical settings is not known. We compared the clinical efficacy of plain nanoemulsion diclofenac gel with topical preparations that include methyl salicylate, in osteoarthritis of knee. Methods: 200 patients were randomly allocated to either plain diclofenac (1% w/w) nanoemulsion gel (Group D) or diclofenac (1% w/w) with methyl salicylate (10% w/w) (Group DS) or topical methyl salicylate (30% w/w) (Group S) or placebo (petroleum jelly) (Group P). Mean change in VAS score and mean change in WOMAC index was calculated for each gr.. Read More»