NADEEM SAIFI

Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh, India

Publications

• Opinion
  Mice expressing dmp1 exhibit impaired skeletal growth
  Author(s): NADEEM SAIFI*
  
  A noncollagenous protein expressed in dentin called Dentin Matrix Protein 1 (DMP1) bone, dentin, and cartilage are examples of mineralized tissues. Transgenic mice that overexpress DMP1 under the control of the CMV gene were used to explore the role of DMP1 during bone development. There were produced promoters. These mice showed a phenotype of enhanced bone mineralization. Additionally, it was discovered that the chondrocytes in the epiphyseal growth plate underwent rapid terminal differentiation. Bone marrow stem cells were stimulated with DMP1 and tested for “early” and “late” markers for osteoblast differentiation in order to look into the potential function of DMP1 in osteoblast differentiation. Within two days of receiving DMP1, CBFA1, BMP2, COL1, and OCN expression levels increased. The ability of bone marrow stem cells to differentiate and create a mine.. Read More»