NADEEM SAIFI

Nadeem Saifi, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh, India

Publications

• Opinion
  Spinal fusion: the function carried by osteogenic protein-1 & bone morphogenetic protein-7
  Author(s): NADEEM SAIFI*
  
  Due to its demonstrated osteoinductive effects, particularly in patients with spondylolisthesis, Osteogenic Protein-1 (OP-1), also known as Bone Morphogenetic Protein-7 (BMP-7), is a protein in the TGF-family of cellular proteins that has shown potential for use in patients undergoing spinal fusion. In order to promote bone development, OP-1 acts on Mesenchymal Stem Cells (MSCs), osteoblasts, and osteoclasts to start a variety of biological processes. The capacity of OP-1 to start ossification in posterolateral arthrodesis has been well supported by animal research. Early clinical trials with OP-1 produced promising results, leading the FDA to approve the treatment for long bone nonunions in 2001 and revision posterolateral arthrodesis in 2004 under a conditional Humanitarian Device Exemption... Read More»