Bryonia alba L., a new approach to rheumatic diseases

10^th International Conference on Orthopedics, Trauma and Rheumatology

March 08-09, 2018 London, UK

Mert Ilhan, Fatma Tugce Guragac and Esra Küpeli Akkol

Gazi University, Turkey Yuzuncu Yıl University, Turkey

ScientificTracks Abstracts: J Orthop Trauma Surg Rel Res

Abstract :

Bryonia alba L. (Cucurbitaceae) has been used to treat rheumatic pain in Turkish folk medicine. According to phytochemical investigations, it has been found to have cucurbitacins and some flavone C-glycosides. Antioxidant, anti-inflammatory and anti-nociceptive activities of B. alba were investigated in this study. n-hexane, ethyl acetate and methanol extracts were prepared from B. alba roots, successively. For the evaluation of anti-inflammatory, anti-nociceptive activities of these extracts, carrageenaninduced hind paw edema, acetic acid-induced increased vascular permeability, p-benzoquinone induced writhing, tail flick tests were performed. DPPH, ABTS, non-site-specific hydroxyl radical scavenging activity and FRAP assays were used for the assessment of antioxidant activity for the extracts. According to the results, the ethyl acetate extract showed the potent anti-inflammatory activity on both anti-inflammatory mice models and also the same extract displayed statistically significant activity on p-benzoquinone induced writhing model. Furthermore, total phenolic and total flavonoid content assays were conducted on ethyl extract of B. alba roots which have the highest anti-inflammatory and anti-nociceptive activity among tested extracts. As a result, ethyl acetate extract of B. alba roots could be used for the treatment of inflammatory diseases.

Biography :

Mert Ilhan has received his BS degree from Faculty of Pharmacy, Ankara University, Turkey and pursuing his PhD studies in the Department of Pharmacognosy, Faculty of Pharmacy, Gazi University with Professor Esra Akkol. He has 13 published articles in SCI indexed journals and 1 chapter in international book.
Email:mertilhan@gazi.edu.tr